In the embryo wounded skin has the ability to regenerate all cell types. But after birth this capacity is lost and is accompanied by the ingress of extra nerves into the wound tissue (hyperinnervation). This study using single-cell sequencing identifies a population of wound-specific fibroblasts only present post-natally and whose gene activity promotes innervation. Thus, reducing innervation holds the key to restoring regenerative capacity after injury
Read the published research article here
Written by
BPoD stands for Biomedical Picture of the Day. Managed by the MRC Laboratory of Medical Sciences until Jul 2023, it is now run independently by a dedicated team of scientists and writers. The website aims to engage everyone, young and old, in the wonders of biology, and its influence on medicine. The ever-growing archive of more than 4000 research images documents over a decade of progress. Explore the collection and see what you discover. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.
BPoD is also available in Catalan at www.bpod.cat with translations by the University of Valencia.