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19 June 2026
Too Much Muscle
A mutation in the TBX4 gene causes a childhood onset lung disease called pulmonary arterial hypertension. Here, a mouse model lacking the TBX4 gene has been developed to delve into the mechanisms underlying the disease. Revealing faulty formation of the lungs' vessels and development of excessive smooth muscle in the lungs, this model represents the human malady and, therefore, could aid treatment advancement.
Read the published research article here
Written by
- Image from work by Lea C. Steffes and Kaylie A. Chiles, and colleagues
- Department of Pediatrics, Division of Pulmonary Medicine, Stanford University School of Medicine, Palo Alto, CA; Department of Obstetrics, Gynecology, and Reproductive Biology, Michigan State University, East Lansing, MI, USA
- Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)
- Published in Journal of Clinical Investigation inSIGHT, April 2026
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