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28 March 2026
Building Safe Walls
Congenital heart defects – a heart or big vessel abnormality at birth – take many forms. Here using lightsheet microscopy to trace cell lineages, researchers have analysed the most common defect the failure of the septum (separating tissue) to correctly form between the heart's two larger chambers, the ventricles. They identify a population of progenitor cells that build the chamber boundary during embryo development and propose that this is orchestrated by the action of the gene Tbx5
Read the published research article here
Written by
- Still from video from work by Irfan S. Kathiriya and Benoit G. Bruneau, and colleagues
- Department of Anesthesia and Perioperative Care, University of California, San Fransisco and Gladstone Institutes, San Francisco, CA, USA
- Video originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)
- Published in Nature Cardiovascular Research, December 2025
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BPoD stands for Biomedical Picture of the Day. Managed by the MRC Laboratory of Medical Sciences until Jul 2023, it is now run independently by a dedicated team of scientists and writers. The website aims to engage everyone, young and old, in the wonders of biology, and its influence on medicine. The ever-growing archive of more than 4000 research images documents over a decade of progress. Explore the collection and see what you discover. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.
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